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These are the best menopause supplements for women over 40, highlighting pros and cons of each.
Hot flashes, night sweats, weight gain, mood swings, insomnia, bloating, low libido… Welcome to menopause.
Think your ‘glory days’ are over? Here’s what your doctor isn’t telling you: the secret to managing these symptoms is in your gut.
New research shows the trillions of microorganisms in your digestive system could be the key to your hormones, weight, and yes – even those hot flashes. Here are how traditional options that target hormones fare against gut-focused solutions like supplements.
| Gut-Focused Supplements *Winner* | Hormone Replacement Therapy | Pharmaceutical Medication | |
|---|---|---|---|
| Gut Health Support How much support it provides the gut. | High | Low | Low |
| Effectiveness How useful it is for menopause support. | Moderate to High | High | Moderate to High |
| Risk of Side-effects Chances an undesirable effect occurs from use. | Low to Moderate | High | High |
| All-Natural Made with organic ingredients. | Yes | No | No |
| Cost Cost | Affordable | Moderate | Varies |
| Long-Term Use Suitability for long-term consumption. | Safe | Unsafe | Unsafe |
Most menopausal symptoms result from a rapid decline in the hormone estrogen. HRT reintroduces estrogen through pills or topical applications.
But here’s what doctors won’t tell you – HRT is expensive and it is not covered by many insurance plans. Studies also show1,2 HRT may also increase risk of heart disease, stroke, blood clots, and breast cancer, not to mention it doesn’t offer any other additional benefits to you.
Doctors may prescribe medications for certain symptoms such as depression, hot-flashes, restlessness, anxiety, and osteoporosis.
For example, doctors may prescribe antidepressants, veozah for hot flashes, and Benzodiazepine to tackle restlessness.
But pharmaceuticals come with their own side-effects and risks and, as the saying goes, sometimes “the treatment is worse than the symptoms.”
Several all-natural supplements are available to get you looking and feeling your post 40 best.
Most of them have their own proprietary mix of ingredients, but we would recommend finding one that contains ingredients that bolsters gut health.
Taking the right supplement daily can support weight management, decrease hot flashes, aid sleep, improve mood, and support healthy bones — naturally.
Fact: Here’s the shocking truth – you could be eating perfectly and exercising daily, yet still struggle with weight gain if your gut microbiome is out of balance.
Recent research reveals that menopause disrupts your gut bacteria composition, leading to slower metabolism, increased inflammation, and stubborn fat storage – regardless of your calorie intake.
Women with a healthy gut microbiome may have a better chance of managing weight during menopause, as beneficial bacteria can:
Fact: New studies reveal that gut bacteria play a crucial role in regulating body temperature and fighting hot flashes.
A study done on post-menopausal women included them going on a vegan, fiber rich diet. At the end of their diet, they had a stronger gut, with a significant reduction in hot flashes.¹³
Fact: Your gut produces over 90% of your body’s serotonin, the “happy hormone.”
Maintaining a healthy gut health may keep your serotonin levels as normal as possible, which may significantly impact your emotional well-being during menopause.
Fact: Digestive issues during menopause often stem from hormonal changes, which can affect your gut bacteria composition.
By supporting your microbiome with gut-boosting ingredients like probiotics, you can potentially reduce bloating and improve digestion.
Our team independently reviewed 29 menopause relief brands using data from independent consumer testing laboratories, Labdoor and ConsumerLab, combined with our internal ratings system to determine the top 5 menopause supplements for women over 40.
We discovered there’s only ONE thing that makes or ‘breaks’ a menopause supplement – its blend of ingredients.
Here are some popular ingredients you should look to have in your supplement.
More than half of the roughly 69 trillion cells in your body are microbial3. These tiny bacteria regulate and support nearly every vital function including vaginal health, weight management, mood, blood pressure (hot flashes), and bone density.
However, hormonal imbalance during menopause can cause harmful bacteria overgrowth leading to increased frequency and intensity of hot flashes, bloating, joint pain and weight gain.
Replenishing your microbiome with probiotics restores balance and improves overall health. When you restore cell function, symptoms lessen. You look and feel better because you are literally “healthier.”
Some popular and effective strains to lookout for include:
Lactobacillus gasseri (L. gasseri)
Bifidobacterium lactis (B. lactis)
Bifidobacterium breve (B. breve)
Prebiotics are non-digestible plant fibers that nourish beneficial gut bacteria, playing a crucial role in maintaining gut health.
They enhance the diversity of the gut microbiome, improve digestion, and produce short-chain fatty acids that support colon health.
Additionally, prebiotics can help regulate hormone levels, which is particularly beneficial during menopause, as they may alleviate symptoms like mood swings and weight gain by promoting metabolic health and stabilizing blood sugar levels.
Several vitamins and minerals play a crucial role in maintaining gut health, influencing the gut microbiome and overall digestive function.
Here are the vitamins and minerals that’s studied for their benefits:
Vitamin A: Supports the integrity of the gut lining and helps maintain a healthy immune response in the gastrointestinal tract.
Vitamin B Complex:
B2 (Riboflavin): Enhances microbial diversity and richness in the gut.
B3 (Niacin): Contributes to overall gut health and may influence microbial composition.
B12: Essential for energy metabolism and supports the synthesis of gut-related enzymes.
Vitamin C: Acts as an antioxidant and promotes the production of short-chain fatty acids (SCFAs), which are beneficial for gut health
Vitamin D: Regulates inflammation in the gut and supports a healthy microbiome. It plays a critical role in calcium absorption, which is vital for maintaining strong bones and overall digestive health
Vitamin E: Helps protect against oxidative stress and may enhance the abundance of beneficial bacteria in the gut
Vitamin K: Important for synthesizing proteins that regulate blood clotting and bone metabolism, it also plays a role in maintaining gut health through its interaction with gut bacteria.
Calcium: Essential for bone health, calcium absorption is dependent on vitamin D, which underscores its importance in digestive health.
Magnesium: Supports muscle function, including the muscles of the gastrointestinal tract, aiding in proper digestion and preventing constipation.
Berberine is a compound that’s extracted from various plants, including barberry.
Traditionally used to treat digestive disorders, modern studies suggest that berberine can influence gut microbiota positively, potentially enhancing gut health by promoting the growth of beneficial bacteria while inhibiting harmful ones.
However, tread cautiously when dealing with this ingredient because Berberine has not been FDA-approved to treat any condition, so we still don’t know much about its safety and overall effects.
Provitalize is the only probiotic in our list that contains all 3 of the best strains for women experiencing menopause. It’s uniquely marketed as a thermogenic probiotic with fat-burning & metabolism-boosting properties.
According to their official website, over 1,200,000 women have shed the stubborn weight with just two capsules a day. The thousands of glowing reviews on Amazon, Trustpilot & Okendo are undeniable proof that Provitalize is worthy of our top spot.
In addition to probiotics, Provitalize contains a herbal blend with demonstrated benefits for premenopausal, menopausal, and postmenopausal women including turmeric root extract, moringa leaf extract, and curry leaf extract. Together these have been shown to combat inflammation and bloating, decrease hot flashes, joint pain, and support healthy blood sugar and cholesterol levels.
Bioperene (black pepper extract) and sunflower lecithin are shown to enhance absorption of vitamins, minerals, and other beneficial properties of herbal formulas.
Want faster visible weight results from Provitalize? Then the Slim Gut Bundle is for you.
This holistic bundle combines the weight-management powers of Provitalize with ‘super fiber’ prebiotics in Previtalize.
The probiotics in Provitalize feed on these ‘super fibers’ to multiply faster and survive longer in the gut. This means women can see faster visible results such as reduction of belly fat & cravings.
These healthy fibers include fructooligosaccharides (FOS), galactooligosaccharides (GOS), and inulin. Previtalize also aids digestion and stabilizes mood naturally.
Slim Gut also contains burdock root, an anti-inflammatory herb that can help to alleviate joint pains.
We listed the Slim Gut Bundle 2nd only because it costs more than Provitalize alone. Other than that, we believe it’s the best-value-for-money bundle in the market right now.
Each 2 capsule of GleeFull Over 30 Hormone Support contains a mix of vitamins and minerals (Vitamin A, Thiamine, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Zinc), 802 mg of their proprietary blend of herbs (horny goat weed powder, dong quai root, ashwaganda, cantuaba bark, damiana leaf, ginger, maca root, etc.), 100 mg each of amino acids (L-arginine, L-tyrosine), and 0.5 mg of Bioperine™ Black Pepper Extract.
The ingredients listed in GleeFull Over 30 Hormone Support are generally safe. Herbs like horny goat weed, ashwaganda and dong quai have been studied to elevate estrogen and help with hormonal balance. The added vitamins and amino acids also help to support better well-being.
Hormone Harmony is produced in Australia and owned by an Australian company.
We like that Hormone Harmony has combined multiple ingredients backed by scientific studies to improve menopausal symptoms.
However, Hormone Harmony is the most expensive option on the market, presumably because they spend a lot on advertising and packaging.
Do note that while their official store shows a 98% customer satisfaction rate, it’s worth noting their Amazon store listing shows a 3.6-star rating out of 5, based on 19 customer reviews (as of January 2025).
They have also been asked to discontinue some claims they made regarding menopausal symptom relief as the National Advertising Division deems them to be unqualified.
Overall, it’s a good supplement to consider. But because of its price, we recommend trying it only after you’ve exhausted all alternatives.
Menoquil is an all-natural supplement that claims to support women’s health at all stages of menopause, with emphasis on multi-symptom relief.
The ingredients look to be diverse and mostly clean, with a mix of vitamins & minerals (vitamin D & K, Calcium, Phosphorus), along with natural ingredients (red clover flower powder & extract, green tea leaf, guggul oleo gum resin, chaste tree berry, dong quai, wild yam root, soy isoflavones, black cohosh, cnidium fruit, black pepper).
For its higher price point, we’re glad to see that they’ve included a wide mix of natural ingredients, along with important vitamins and minerals.
However, we’re not too happy about the additives they’ve included in their supplements, including magnesium stearate (an anti-caking/coloring) and shellac (pharmaceutical glaze).
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