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BREAKING: Glucosamine Chondroitin Doesn't Work. What Does?

Written by: Janelle Barowski, MSN, RN

In the past, doctors have recommended glucosamine chondroitin to treat or slow the progression of joint degeneration and conditions like osteoarthritis.

However, this changed recently after some shocking findings.

Why Is Glucosamine Chondroitin No Longer Recommended?

Initially, several studies on glucosamine chondroitin demonstrated positive results on osteoarthritis patients.

But in recent years, authorities found inconsistencies and a conflict of interest behind the studies that originally supported the use of glucosamine chondroitin.

As of 2022, both the American College of Rheumatology and the Australian Rheumatology Association no longer recommend glucosamine chondroitin as a supplement for osteoarthritis.

According to Harvard:

  • A 2018 review of previous research2 found that treating knee or hip osteoarthritis with glucosamine and chondroitin led to small improvements on a pain scale, but it wasn’t clear that the pain relief was actually meaningful.
  • A 2022 analysis of eight studies3 that included nearly 4,000 people with knee osteoarthritis found no convincing evidence that glucosamine and chondroitin provided major benefit.
  • The case for these supplements protecting joint health or preventing arthritis from worsening is similarly weak4.

A 2016 study5 of glucosamine and chondroitin enrolled 164 patients with knee pain due to osteoarthritis and gave half of them a combination of glucosamine and chondroitin; the other half received an identical placebo pill.

The study was stopped early for an unusual reason: those taking the supplement actually reported worse symptoms than those taking a placebo. This raises the possibility that taking glucosamine and chondroitin might make your joints feel worse than doing nothing.

Safe & Effective Alternatives To Glucosamine Chondroitin

Curcumin is the bright yellow hue and active ingredient in turmeric. 

Multiple studies on curcumin have shown very promising signs that it could alleviate joint pain and slow joint degeneration without major side effects.

In one study, it demonstrated the potential to reduce inflammation in osteoarthritis by minimizing cytokine levels. This was demonstrated to help improve pain and physical mobility among patients7.

In another study, curcumin supplements were deemed to be just as effective as pain meds or NSAIDs at managing osteoarthritis. Various independent clinical studies were conducted and they demonstrated effectiveness in managing joint pain. This may be a particularly useful option for people who experience digestive side effects with NSAIDS8.

If you’re thinking of getting a curcumin supplement, make sure it contains black pepper extract as our body has difficulty absorbing curcumin on its own. Black pepper extract improves the absorption by up to 2,000%9.

Recent research indicates that poor gut microbiome may be the driving force behind osteoarthritis.

Researchers found that mice with osteoarthritis had gut bacteria that lacked specific beneficial probiotics. Probiotic supplements may help correct this imbalance.10

Your gut microbiome helps keep your body healthy. When it becomes unbalanced, there may be a spike in osteoarthritis symptoms and inflammation.11

Adding a probiotic to your regimen can help restore this balance and may minimize your arthritic symptoms.12

Some probiotic species that have shown potential in pain relief: L. acidophilus13, L. casei14, B. coagulans15

Some probiotics also carry anti-inflammatory properties.

Anti-inflammatory probiotics encourage healthy bacteria to multiply in your gut. When the good bacteria outnumber the bad bacteria, the swelling in your joints can go down.16

Are you wondering what your gut has to do with your joints? Well, people with arthritis can also have an inflamed gut. This can cause a leaky gut, and widespread inflammation that can trigger your joint pain. A probiotic can help keep you moving and doing the things you love.17

Probiotics are common these days, but they are also the most underrated ingredients for improving joint health and accelerating your recovery from bursitis.

Probiotics regulate and support nearly every vital function including bone density, joint inflammation, weight management and even vaginal health, mood, and more.

Emerging studies18 show that a healthy gut can also regulate estrogen levels and support hormonal balance. This is key to keeping inflammation in our body under control, and helping women undergoing menopause to recover faster from flare-ups.

Some probiotic strains also demonstrate anti-inflammatory properties and they address inflammation head-on just like curcumin does. Some of these strains include B. Lactis R101-819, L. Rhamnosus 4B15, and L. Gasseri 4M1320.

Methylsulfonylmethane or MSM in short, is a chemical in animals, humans, and many plants. People use it most often to try to treat arthritis.

MSM can be produced in a lab, where it is sometimes combined with other supplements such as glucosamine or chondroitin.

An early trial in 2006 examined MSM’s ability to improve pain symptoms and physical function in osteoarthritis patients. Patients took 3g of MSM twice a day and showed some improvements, but the benefits and safety of MSM in long-term use could not be confirmed based on the relatively short trial21.

However, no significant trial has been conducted since then to demonstrate the effectiveness and safety of MSM. We recommend that you speak with a doctor if you plan to take MSM.

Collagen makes up about 60% of cartilage, which helps to cushion our joints from the shock of high-impact movements.22

Usually, collagen decline in our 40s and older contribute to more joint pains later on.

Collagen supplements can help to slow the progression and degeneration of our joint cartilage, according to multiple clinical studies.23

There are two main types of collagen – bovine (from cow) and marine (from fish and shellfish).

Marine collagen is better for the human body than bovine collagen for various reasons:

  • It contains more glycosaminoglycans (GAGs) than bovine collagen, which function as “shock absorbers” in joints and skin tissue.
  • It’s easier to digest as marine collagen is broken down into amino acids.
  • It is better for the environment.

Clinical studies support this. Marine collagen has demonstrated positive results in wound healing and bone regeneration.24

Your body can’t make Omega-3 fatty acids or fish oil. Instead, you need to eat cold water fish or introduce supplements into your routine. Fish oil can reduce inflammation and morning stiffness, two common symptoms of osteoarthritis.25

These healthy fats may work to stop inflammation by blocking the signaling molecules that cause inflammation. Research shows that increasing your intake of fish oil supplements can improve movement by reducing pain and stiffness caused by osteoarthritis.26

Keep in mind, not all joint supplements are created equal. Different brands use different ingredients, and some formulas are simply going to be more effective than others. So look out for the best formulation possible, backed by real customer results. At Supplement Review, we’ve analyzed some of the top-selling joint supplements on the market to help guide you in the right direction. We’ll show you what to look for and what to avoid in a high-quality supplement, plus, we share our top 5 picks of the year.

What To Look Out For In An Effective Joint Supplement

The FDA doesn’t require third-party verification. However, responsible and honest supplement manufacturers get third-party verifications as an act of good faith to provide transparency and distinguish products. Certifications verify ingredients and quantities claimed on the label. Look out for these important certifications before buying a supplement – GMP, USP, NSF, Certified Organic, NON-GMO certified.

Never buy a supplement just on ‘hearsay’ or just because it has ingredients that are used in traditional medicine. Let the facts speak for themselves. Always look out for clinically-studied ingredients whose efficacy are supported by a body of evidence.

Sadly, according to the New York Times27, one in four products sold on Amazon is fake. This is especially true of nutritional supplements. Avoid buying supplements on Ebay. When you buy from Amazon, ensure you buy from the manufacturer’s Amazon store. Otherwise, buy directly from the manufacturer’s website. Buying fraudulent products may cause nasty side effects — be extra cautious about authenticity.

All supplements made in the USA are regulated by the FDA. The same applies to those made in Canada and Australia. Ensure products you buy come from FDA regulated facilities using GMP certified manufacturing processes. Many supplements, especially those purchased on eBay and Amazon come from China and abroad. One study found 60%-70% of these ‘foreign’ supplements do not contain the ingredients or quantities claimed on labels28.

A risk-free guarantee lets you try supplements without fear of losing your money. If you try the product and don’t experience the results simply contact the manufacturer for a refund. Look for companies who have a “no-bottle-return’ policy. This allows you to finish the supplements without incurring any risk. And it’s also the best sign of how confident the company is in standing behind their promises.

These Are The Best Glucosamine Alternatives In 2024

Overall Grade: A+

Why We Like Provitalize:

Provitalize contains 2 safe and effective alternatives to glucosamine – curcumin and probiotics with anti-inflammatory properties.

Provitalize contains 350mg of curcumin with black pepper extract which enhances absorption in our body. It also contains 68.2 billion CFUs of probiotics – B. breve, B. lactis, and L. gasseri.

It is also easy to consume (just two capsules a day), which makes it easy for anyone to remember and not have to take it multiple times a day.

Provitalize stands out for its comprehensive ingredient list. It’s not just a blend of three anti-inflammatory probiotic strains or curcumin. It’s also loaded with organic moringa leaf extract and curry leaf extractIt is difficult to find another product that contains this combination of ingredients.

Additionally, it’s third-party tested for purity. The bright orange capsules are remembered most by customers as its trademark feature.

But what if it doesn’t work for you?

Provitalize has the most generous money-back guarantee we have seen in the industry. 

While most supplement brands make customers jump through hoops such as shipping empty bottles and paying for postage to qualify for refunds, customer reviews suggest that as long as you request for a refund within 90 days of purchase, you will get your money back easily.

This demonstrates the confidence in their product

With that, Provitalize takes a well-deserved spot at the top.

Pros

  • Contains 68.2 billion CFUs of clinically studied, anti-inflammatory L. Gasseri, B. Breve, and B. Lactis probiotic strains.
  • Contains 350mg of Curcumin (Turmeric Root Extract)
  • Contains 350mg of Moringa leaves extract
  • Contains 150mg of Curry leaves extract
  • 100% natural with no filler or additive or emulsifier
  • Trademarked delayed-release capsules for protection against stomach acid
  • Stimulant and caffeine-free, GMO-free, hormone-free
  • Keto-friendly, vegan-friendly, and paleo-friendly
  • Made in a certified GMP facility in USA
  • 90-day money back guarantee (no bottle return needed)

Cons

  • Sold exclusively online

*Results are based on users’ personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see the product website for more information.

2.Key Benefits of Provitalize probiotic and Previtalize prebiotic
Overall Grade: A

The Bottom Line:

The Slim Gut Bundle is even more impressive than Provitalize alone because of the Previtalize prebiotic included in this bundle. Previtalize contains burdock root, another anti-inflammatory herb that also saw results with osteoarthritis patients.23

Probiotics work best with prebiotics, as prebiotics serve as the nutrients for probiotics to thrive in our gut. We like that Better Body Co. bundled these products together for a discount and offers an even steeper discount of 15% for customers who commit for the full 90-day experience.

As frequent supplement consumers, we share the belief that any supplement requires more than 90 days to see significant results, especially because they are formulated to support our natural body functions instead of “treating” specific ailments like pharmaceutical drugs.

The good news is that Better Body Co also understands customers’ desire for results and many customers who hop from one product to another often don’t find success because they don’t give the product enough time to work.

To assure customers, they have an industry-leading 90-day money-back guarantee. Unlike most supplement companies, they do not require customers to return the bottles to them to qualify for a refund.

Given the well thought-out formulation and bundling offer, the Slim Gut bundle deserves the second spot on our top 5.

Pros

  • Plant-based estrogens from Moringa leaf and Burdock root
  • Clinically studied L. Gasseri, B. Breve, and B. Lactis probiotic strains.
  • 350mg of Curcumin (Turmeric Root Extract)
  • 350mg of Moringa leaves extract
  • 150mg of Curry leaves extract
  • 100% natural with no filler
  • Stimulant and caffeine-free, GMO-free, hormone-free
  • Keto-friendly, vegan-friendly, and paleo-friendly
  • Made in a certified GMP facility in USA
  • 90-day money back guarantee (no bottle return needed)
  • Further 15% discount on minimum 90-day Autoship subscription

Cons

  • Sold exclusively online
  • Costs more than just Provitalize alone

*Results are based on users’ personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see the product website for more information.

Overall Grade: A-

The Bottom Line:

The Ultimate Omega is the number 1 fish oil supplement in the United States for a good reason. Their formula has won over 10 awards, including best Omega-3 by Delicious Living

A sustainable option, these supplements are made from 100% wild caught fish and anchovies. They’re made in a sustainable zero waste facility powered by biofuel and they’re Friend Of The Sea certified.  

The Ultimate Omega supplements are purity tested by a third party company. So, you know exactly what you’re getting.  

Have you ever had a fishy burp after taking Omega-3 supplements? Well, you won’t with these. These supplements are protected from the oxidative stress that causes that fishy aftertaste. 

Pros

  • 1280 mg of Omega-3 
  • Triglyceride EPA & DHA
  • No fishy aftertaste
  • Made from 100% wild caught fish
  • Gluten- & dairy-free
  • No artificial colours, flavors, or preservatives 
  •  

Cons

  • Not suitable for those on blood thinners
  • Do not use if you have an allergy to iodine, not recommended for those on blood thinners

*Results are based on users’ personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see the product website for more information.

Overall Grade: B

The Bottom Line:

Nature’s Bounty has been making supplements for 50 years. So, if you’re looking for a timeless brand you can trust, look no further. 

The Nature’s Bounty Fish Oil supplements are tested for purity throughout the manufacturing process. These tests check for purity along with potency of the product. 

These supplements undergo a purification process to remove any mercury from the finished product. They’re also guaranteed to be made without shellfish. 

Pros

  • 360 mg of Omega-3
  • No mercury, shellfish, gluten, lactose, sugar, artificial colors or sweeteners
  • Made with anchovy, mackerel, or sardine

Cons

  • Can only be shipped within the United States and to some countries at the time of writing

*Results are based on users’ personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see the product website for more information.

Overall Grade: B-

The Bottom Line :

Redimove is clinically tested to help reduce inflammation and improve activity.  In a placebo-controlled study, 4 out of 5 participants noted joint relief after taking Redimove for 2 weeks. There were no side effects reported.23

This supplement is made of UC-II® Collagen,  Boswellia Serrata, MSM,  Turmeric, and  BioPerin. These ingredients work together to naturally reduce pro-inflammatory cytokines.24

Pros

  • Non-GMO
  • Gluten-Free
  • 30-day money back guarantee
  • Contains UC-II® Collagen,  Boswellia Serrata, MSM,  Turmeric, and  BioPerine

Cons

  • May not be approved for pregnant or nursing women

*Results are based on users’ personal experiences collected on this page and do not necessarily reflect typical results of using these products. Please see the product website for more information.

OR

Janelle Barowski, MSN, RN

Health and wellness writer

Janelle Barowski, MSN, RN, is a health and wellness writer for several outlets, including Healthgrades and Medical News Today. She uses a balance between empathy and authenticity to craft well-written, accurate medical content.
As a registered nurse, Janelle is passionate about client education and public health. She strives to break down complex medical concepts into an approachable format for her audience