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Hitting 40 changes everything. The same diet and exercise that used to keep you in shape suddenly stop working. The scale creeps up, belly fat sticks around, and no amount of effort seems to make a difference.
If this sounds familiar, you’re not alone. Many women struggle with midlife weight gain—not because of willpower, but because of what’s happening in their gut.
Gut health plays a huge role in metabolism & fat storage.
An imbalance in your gut microbiome can slow metabolism, increase inflammation, and make weight loss feel impossible. That’s where probiotics come in.
The right probiotic strains may help:
In this article, we’ll cover what to look for in a probiotic, and our top recommendations to help you finally see results.
While the right probiotic can support weight management, it’s important to choose wisely.
Different strains have different effects, and some probiotics may cause unwanted side effects like bloating, gas, or digestive discomfort—varying from product to product.
To help you make an informed decision, we’ve compared five top-rated probiotics based on customer-reported side effects. Below, you’ll find a breakdown of their severity, ranging from low to high, so you can find the best option for your needs.
Diarrhea | Constipation | Abdominal Pains | Bloating | Nausea | |
 Provitalize | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. |
 Slim Gut Bundle | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. | Low Well-tolerated with minimal side effects. | Medium Moderate bloating may occur. | Low Well-tolerated with minimal side effects. |
 Thin 30 Probiotic | High Potential for frequent or severe diarrhea. | Medium Moderate constipation may occur. | High May cause severe abdominal pain. | Medium Moderate bloating may occur. | Medium Moderate nausea may occur. |
 Amare Quadbiotics | High Potential for frequent or severe diarrhea. | Medium Moderate constipation may occur. | High May cause severe abdominal pain. | Medium Moderate bloating may occur. | High Persistent nausea may occur. |
 Bioma Probiotics | High Potential for frequent or severe diarrhea. | High Risk of persistent constipation. | High May cause severe abdominal pain. | High Potential for frequent or severe bloating. | High Persistent nausea may occur. |
If you take probiotics regularly, you can expect some results to begin in about a month. It may take longer for you to have noticeable weight loss as it takes a while for your guts microbiome to balance.
Sometimes, the supplements are made poorly, the dosage is too low, or they may be stored incorrectly. This keeps the probiotic from working as well. You should pick your supplements carefully to avoid slower results.
Here is a general indication of results you can expect:
Month 1: You may notice an improvement in unwanted stomach issues, like diarrhea or bloating. You may experience greater regularity and better sleep too.
Month 2: At this point, you may start to lose some weight. It is not uncommon to see between 2-8 lbs of weight loss in the second month, but this may differ for every person. You may also experience lower inflammation levels.
Other factors that may also affect weight loss include genetics, diet, stress levels, and physical activity.
Month 3: Modest amounts of weight loss start to happen for the majority of people in the 3rd month.
People tend to think that weight loss can happen quickly, but just like weight gain happens over time, weight loss is the same. Combined with less bloating, you may see a flatter tummy and be able to fit into clothes that didn’t fit anymore previously.
Overall, your fat stores on your body may start to melt away. This means your hips, thighs, and other problem areas may become smaller.
Tip 1: Take your probiotic for at least 3 months to see significant results. It may take that long for your metabolism to speed up and affect your fat stores.
Tip 2: Take a prebiotic for faster results. Probiotics use prebiotics for fuel to multiply quickly.
Tip 3: Engage in some form of physical activity daily. This means taking a walk or stroll in the park, working in the garden, or window shopping – for at least 30 minutes a day. You don’t have to hit the gym to lose weight.
With hundreds of probiotic supplements out there… How will you know what to pick?
Thankfully, we’ve done the legwork for you.
First, we analyzed a systematic review of 2431 full-text articles, including data from 65 randomized clinical trials of 14 popular probiotics marketed for weight management published in the PubMed database.
In addition, we examined 12 other clinical studies published on general probiotics in the market today.
Here are the main probiotic strains that have demonstrated effectiveness in supporting belly fat management and weight loss.
Some probiotic strains help people lose weight faster than others. L. Gasseri prevents your body from accumulating fat, so you’re not gaining weight as easily.
L. Gasseri can even help target that stubborn belly area. In a study where participants changed nothing else besides taking L. Gasseri supplements for 12 weeks, they saw a noticeable difference in weight along with waist and hip size.
You can take B.Lactis supplements to help lower your body mass index (BMI). If you’re looking to slim up for bathing suit weather, this strain of probiotic may help you shed that lower belly fat.
As women near menopause, they may start to notice those extra pounds around the waist. Often called the “spare tire”, B. Lactis subsp. Animalis can help shrink your hip and waist. This strain may help curb cravings by suppressing your appetite and increasing feelings of fullness.
B. Breve can do it all. It may lower body weight, while improving cholesterol and blood sugar levels. This strain of probiotic may help your body use cholesterol faster, bringing your levels down quickly. In a recent study, participants who took B.Breve lost an average of 0.7 kg over 12 weeks.
Many women over 40 gain weight easily because estrogen levels decline as we enter the early stages of menopause and start experiencing “the change”.
Estrogen regulates the way our body distributes and stores fat. When estrogen levels are low, more fats are stored in the belly area and we gain weight more easily.
Provitalize is the only probiotic formula with weight management properties that addresses multiple aspects of estrogen decline, namely:
Provitalize contains L. Gasseri SBT2055, a probiotic strain clinically studied thrice. Participants saw a reduction in abdominal visceral fats by up to 4.6%15 and 8.5%16 respectively.
But more importantly, L. Gasseri SBT2055 works by blocking fat absorption and promoting fat excretion through the feces17 naturally. It creates a fat deficit, enabling your body to convert more stored fats for energy.
Provitalize also contains two other clinically studied probiotic strains (B. Breve IDCC4401 and B. Lactis R101-8) that stimulate cholesterol and saturated fat metabolism18,19. B. Breve IDCC4401 was also found to lower total cholesterol and LDL (low-density lipoprotein) cholesterol levels.
Finally, B. Lactis R101-8 was also found to improve two inflammatory markers19 and Provitalize also contains superherbs with anti-inflammatory properties – 350mg of curcumin (turmeric) and moringa leaves.
To top it off, the same herbs are also phytoestrogens – curcumin and moringa leaves – which help to promote hormonal balance and supplement the estrogen decline.
The probiotics in Provitalize help to improve gut health and address gut dysbiosis, enabling the gut to regulate estrogen levels in our body and support hormonal balance naturally.
Provitalize has also been formulated with absorption (or bioavailability) in mind. It contains BioPerine® (black pepper extract) and sunflower lecithin which are shown to enhance absorption of vitamins, minerals, and other beneficial properties of herbal formulas.
Finally, these ingredients are encapsulated in DRcaps® capsules, a patented and costly type of delayed-release capsule that protects the ingredients from stomach acid and ensures their smooth passage into our gut where they are most effective.
According to their official website, over 1,200,000 women have shed the stubborn weight with just two capsules a day. The tens of thousands of glowing reviews on TrustPilot, Amazon, and Okendo are undeniable proof that Provitalize is worthy of our top spot.
Want faster visible weight results from Provitalize? Then the Slim Gut Bundle is for you.
This holistic bundle combines the weight-management powers of Provitalize with ‘super fiber’ prebiotics in Previtalize.
The probiotics in Provitalize feed on these ‘super fibers’ to multiply faster and survive longer in the gut. This means women can see faster visible results such as reduction of belly fat & cravings.
These healthy fibers include fructooligosaccharides (FOS), galactooligosaccharides (GOS), and inulin. Previtalize also aids digestion and stabilizes mood naturally.
Slim Gut also contains burdock root, an anti-inflammatory herb that can help to alleviate joint pains.
We listed the Slim Gut Bundle 2nd only because it costs more than Provitalize alone. Other than that, we believe it’s the best-value-for-money bundle in the market right now.
We like this supplement because it has caffeine-free green tea, apple cider vinegar, cayenne pepper extract, and some of the probiotic strains that can help you lose weight.
Thin 30 Probiotic has 6 probiotic strains, but less units of each probiotic. So, it may work slower than the other supplements on this list.
It also has L. Acidophilus, one of the probiotics that may cause weight gain.
Another potential drawback is that it has a proprietary formula, so the make-up of its herbs, prebiotics, and probiotics are not known. We recommend monitoring your health closely if you choose to take this probiotic in case of side effects.
Note: Customers on Amazon have been complaining about side effects after taking this probiotic, like:
Each serving of Amare GBX Fit™ (1 capsule) contains 309mg of their proprietary blend of quad-biotics (orange peel extract, acacia gum fiber, lactobacillus plantarum DR7™, bifidobacterium lactis BPL1™). The rest of the ingredients include microcrystalline cellulose, vegetable juice and bamboo leaf extract.
The ingredients are natural, safe and minimal, which we like. However, we’d love it if they broke their proprietary blend down even more, so consumers know how much of each ingredient they’re getting in each capsule.
The formula features Serenzo™, the trademarked orange peel extract, that supposedly helps with stress and mood changes. It also features Inavea, a trademarked prebiotic fibers studied to help with constipation. The studies for both of these trademarked ingredients are unpublished, so we did not link them in our review.
They do include a probiotic Lactobacillus. Planetarium DR7, which is studied to benefit gut health. However, without including the CFU’s, a measure of how much colony forming units of probiotics is contained within a serving, we’re unsure of it’s effectiveness as a probiotic.
Now, the only ingredient that may help with weight loss in their formula is the postbiotic Bifidobacterium.Lactis BPL1™, which may reduce fat deposition around the waistline.
All in all, Amare GBX Fit™ seems like a decent choice for a weight loss probiotic. However, the lack of information regarding their blend of ingredients, plus the fact that there’s only 1 ingredient (B.Lactis BPL1™) in their blend that’s clinically proven to help with weight management, is why we put them at their current spot in the rankings.
Note: Customers on their website have been complaining about side effects after taking this probiotic, like:
Bioma Probiotics is a probiotic supplement, marketed as a probiotic for digestive and weight support.
Probiotics are delicate and need to survive stomach acid to reach the gut, but prebiotics in the same capsule can trigger premature fermentation, destabilizing the formula.
Also, postbiotics, while beneficial, don’t require the same delivery method and may interfere with live probiotics, so putting them all together for an “all-in-one” solution isn’t that great in reality.
Note: After checking their reviews on Amazon, we found that their product may not live up to the hype, as there are tons of customer complaining about varying side effects like:
We’ve gathered some of those complaints from Amazon below so you’ll take precaution before making a decision:
Women can gain weight and belly fats more easily after 40 due to multiple reasons.
While lower estrogen levels could be the root cause, the intermediate concerns are inflammation, leaky gut, and lower metabolism.
We recommend looking for a probiotic that can address all three.
Individual results vary, but according to our research, people supporting diet and exercise efforts may shed an additional 5-10% of weight with the supplements listed in this article.
In combination with a good diet and regular exercise, the right probioticcan enhance your efforts to eliminate stubborn belly fat. One study published in the peer-reviewed British Journal of Nutrition, found that participants consuming Lactobacillus gasseri SBT2055 reduced abdominal fat (visceral fat) by up 8.5% over 12 weeks13.
Generally speaking, all of the weight management probiotics supplements listed in this article are considered safe. If you have any health concerns consult your physician before buying.
A study published in Today’s Annals of Internal Medicine suggests aiming to eat 30 grams of fiber each day can help you lose weight16”. Prebiotic fibers have also been shown to ease cravings, balance moods and enhance the effects of probiotics.
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